Author

John E. Levine

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Open access Oct 2026

Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant.

Successful hematopoietic cell transplant requires immunosuppression to prevent graft-versus-host disease (GVHD), a lethal, T cell-mediated complication. The phase 3 BMT CTN 1703 trial demonstrated superior GVHD-free/relapse-free survival for posttransplant cyclophosphamide (PT-Cy)-based GVHD prophylaxis versus tacrolim...

S. DeWolf, S. Siegel, Joseph Schmalz et al. · Science Translational Medici... · 0 citations

Open access Oct 2026

ATG exposure in T replete transplant for hematological malignancies: Real world analysis from BMT CTN 1202.

Traditional weight-based dosing results in variable rabbit anti-thymocyte globulin (rATG) clearance, delaying CD4+Tcell-immune-reconstitution (CD4 + IR) and impacting outcomes. In a retrospective pharmacokinetic/pharmacodynamic analysis of patients undergoing first T-replete hematopoietic cell transplantation (HCT), en...

M. Lakkaraja, A. Mauguen, K. Hosszu et al. · Bone Marrow Transplantation · 0 citations