John F. Dawson

Early pre-symptomatic and sex-specific cardiac remodeling precedes heart failure in zebrafish with human actin mutation.

Dilated cardiomyopathy (DCM) is a leading cause of heart failure with notable sex differences in susceptibility and progression. Although sarcomere mutations such as cardiac actin ACTC1 p.T126I contribute to familial DCM, the in vivo effects and sex-specific consequences remain unclear. We generated a zebrafish model c...