John H. Ni

Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient

In 2024, an adolescent female in British Columbia was hospitalised presenting with severe symptoms including respiratory failure due to infection with a novel H5N1 influenza strain (BC24). Using cryogenic electron microscopy, we show here that the N169 α2,3-linked auto-glycan that is found in the sialic acid binding si...