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Author

John M. Lindner

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Open access Aug 2026

Bioprinted Human Primary Arteries Recapitulate Inflammatory Activation and Pharmacologic Rescue

Chronic inflammation drives persistent systemic cytokine signaling that contributes to vascular dysfunction and secondary vasculitis, yet mechanistic studies are limited by models that fail to capture the multicellular architecture and dynamics of human arteries. In contrast, perfusing intact vessels ex vivo has limite...

Zhouquan Fu, V. A. Fastiggi, Angelica Phelan et al. · 0 citations
Open access Aug 2026

Engineering editopes through programmable RNA editing toward tumor neoantigen generation.

Short Precise-Encodable ADAR Recruiting (SPEAR) gRNAs are developed that harness endogenous ADAR1 to direct precise adenosine-to-inosine (A-to-I) editing at selected transcript sites and demonstrate the generation of immunogenic neoepitopes through RNA editing at the transcript level, termed editopes.

R. Pecori, Beatrice Casati, Rona Merdler-Rabinowicz et al. · 0 citations

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