Neuroblastoma is a heterogeneous pediatric cancer whose behavior is shaped by diverse genomic alterations. While previous genomic studies have identified recurrent drivers and mutational processes, whether large-scale genome architecture actively contributes to defining tumor states has not yet been fully investigated....
Giuseppe D'Alterio, Vincenzo Aievola, G. Pirozzi et al.· Cancer Genetics· 0 citations
SUMMARY Osteosarcoma (OS) is the most common human primary bone cancer, primarily affecting children and young adults. While the survival rate of patients diagnosed with localized OS is ~65%, this decreases to ~20% for patients with metastatic disease, and recurrent disease remains largely incurable. Therefore, identif...
Brian Mooney, Xiaojie Chu, G. Negri et al.· Cell Reports· 0 citations
High-risk neuroblastoma remains a leading cause of pediatric cancer mortality, and relapse—driven by chemotherapy-resistant "persister" tumor cells that survive induction therapy—accounts for the majority of these deaths. Our recent single-nucleus and whole-genome sequencing analysis of matched diagnosis and definiti...
HLA-Shuttle restores antigen presentation in immunologically cold tumor cells, facilitating identification of TAAs with favorable therapeutic potential and identifying multiple novel tumor associated antigens (TAAs) from both known and novel cancer immunotherapy targets.
Daniel Hwang, Molly C. Erdman, Santosh Adhikari et al.· Journal of Immunology· 0 citations
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