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Jonas Hallén

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Open access Sep 2026

A first-in-human study of CAL101, a monoclonal antibody targeting S100A4.

AIMS S100A4 is a damage-associated molecular pattern protein that amplifies pro-inflammatory and pro-fibrotic signalling. CAL101 is a first-in-class humanized monoclonal antibody that neutralizes S100A4. This first-in-human study evaluated safety, pharmacokinetics (PK), immunogenicity and exploratory pharmacodynamics (...

Jonas Hallén, S. Vetrhus, M. Sørgaard et al. · 0 citations

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