SUMMARY Giardia lamblia is a microaerophilic protozoan parasite that infects nearly 280 million people worldwide each year. Giardia lacks a mitochondrial genome and mitochondrial enzymes for oxidative phosphorylation. However, it retains mitochondrion-related organelles (MROs) that house an iron-sulfur cluster (ISC) as...
Manish Goyal, Tiana M. Issa, Jonathan A. Stefely et al.· Current Biology· 2 citations
Mitochondria arose from the endosymbiosis of a bacterium with an archaea-related host cell about 2 billion years ago. To understand their origins and evolution, we compared experimentally defined mitoproteomes from the MitoCarta Tree of Life project. Across eight organisms, we identified 8,619 distinct mitochondrial pr...
Michael Z. Chen, Jonathan A. Stefely, Eric G. Bardon et al.· Cell· 9 citations
SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...
Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al.· Molecules and Cells· 2 citations
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