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Author

Jonathan Blanchet

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Open access Sep 2026

The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion.

It is demonstrated that the vaccinia virus-encoded K3L protein interacts with 4EHP via its obligatory binding partner GIGYF2 to increase the stability of the 4EHP/GIGYF2 complex and bolsters 4EHP/GIGYF2-mediated mRNA translation repression.

R. Ladak, A. Pelin, Hao-Tian Zhuang et al. · 0 citations

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