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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jonathan K. Watts

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2 papers indexed here

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Review Open access Sep 2026

Nucleic acid therapeutics in neurodegenerative disorders: emerging technologies and clinical landscape

Neurodegenerative disorders have diverse etiologies from monogenic mechanisms such as toxic gain-of-function mutation in subsets of amyotrophic lateral sclerosis (ALS) to multifactorial cascades exemplified by Alzheimer’s disease (AD), which feature proteostasis failure, neuroinflammation, mitochondrial dysfunction, or...

Masahiro Ohara, S. Ishigaki, Jonathan K. Watts et al. · 0 citations
Aug 2026

Improved Purification of sgRNA and pegRNA by Use of a 5'-Terminal Dioctyloxytrityl (DOT) Protecting Group.

The purity and chemical integrity of oligonucleotides are critical determinants of safety, efficacy, and reproducibility in RNA therapeutics. Impurities arising from incomplete synthesis, degradation, or side reactions can compromise pharmacological performance and induce off-target or immune responses. For long, struc...

Atish Wagh, Jonathan K. Watts · 0 citations

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