Author

Jonathan P. Schneck

2 papers indexed here

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Jul 2026

Nanoscale artificial antigen presenting cells to expand human antigen-specific cytotoxic CD4 T cells for immunotherapy 2258982

CD4 T cells play key roles in immune modulation and cancer immunity. Increasing evidence shows they also exhibit cytotoxicity and can be harnessed for cancer immunotherapy. However, methods to reliably expand antigen-specific CD4 T cells remain limited. Here, we developed a nanoscale platform to expand antigen-sp...

Si-Sim Kang, Mu-Qing Zhang, Shuyi Li et al. · Journal of Immunology · 0 citations

Open access Jul 2026

Investigating Cytotoxic Function in CD4+ T-cells for Cancer Immunotherapy 2260082

T-cell-based immunotherapies like ACT have mostly focused on CD8 T cells, but cytotoxic CD4 T cells (CD4 CTLs) are increasingly recognized as contributors to anti-tumor immunity. As such, we created a CD4 T-cell activating nanoparticle platform, termed the artificial antigen presenting cell (aAPC). Under Th1-skew...

Mara R Lanis, Sujin Kim, Nina M. Nair et al. · Journal of Immunology · 0 citations