Open access
Jul 2026
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
ABSTRACT Despite the growing importance of lipid nanoparticles (LNPs) in mRNA therapeutics, current ionizable lipids, which comprise an ionizable head group, a linker, and hydrophobic tails that collectively govern the delivery behavior, exhibit dose‐limiting toxicity and suboptimal efficiency. Hydrophobic tail chemist...
Seo-Hyeon Bae, Jisun Lee, J. Ahn et al.
· Advancement of science · 0 citations