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The mechanisms through which GBM cells evade GD2-targeted CAR-T and CAR-iNKT cells effectively target GBM but are susceptible to repeated antigen exposure, which IL-12 could counteract, and encourage further development of armored IL-12 CAR-T or CAR-iNKT cells.
A scalable culture system to preferentially expand human CD4− iNKT cells directly from total peripheral blood mononuclear cells (PBMCs) using alpha-galactosylceramide (α-GalCer) and optimized cytokine conditions and IL-15 was the most effective cytokine.
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