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Author

Jordan Zhu

2 papers indexed here

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Jul 2026

A Novel Dual-targeting OX40L and IL-13 Bispecific Antibody with Synergistic Effect for Atopic Dermatitis Treatment 2255160

Atopic dermatitis (AD) is a chronic inflammatory skin disorder. While the immune response in AD is predominantly mediated by T-helper 2 (Th2) cells, contributions from Th1, Th17, and Th22 pathways are also significant. Interleukin-13 (IL-13), a key Th2 cytokine, promotes B-cell proliferation and goblet cell metap...

Hui Yuwen, Hongyan Shang, Yan Zhu et al. · 0 citations
Open access Jul 2026

A Novel Dual-targeting PD-1 and TL1A Bispecific Antibody with Synergistic Effect for Immune Disorders Treatment 2255198

Programmed cell death protein 1 (PD-1), an inhibitory immune checkpoint on T cells, maintains immune homeostasis. Dysregulated PD-1 signaling is implicated in autoimmune pathogenesis, whereas insufficient activity may result in uncontrolled T-cell responses. TNF-like ligand 1A (TL1A), a member of the TNF superfam...

Hongyan Shang, Duqing Jiang, Xiao Huang et al. · 0 citations

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