Jorge Cuenca-Escalona

ACC1 inhibition enhances BCG-induced trained immunity by reprogramming Acetyl-CoA metabolism.

Trained immunity enhances long-term innate immune responsiveness through metabolic and epigenetic rewiring. Using BCG as a model, we demonstrate that inhibition of acetyl-CoA carboxylase 1 (ACC1) enhances BCG-induced trained immunity by increasing intracellular acetyl-CoA (ACoA) availability. This shift redirects ACoA...