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Author

Jorge Plutzky

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2 papers indexed here

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Open access Aug 2026

Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis

BACKGROUND: In SELECT (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), among 17 604 patients with known atherosclerotic cardiovascular disease and overweight or obesity, but not diabetes, randomization to the glucagon-like peptide-1 receptor agonist semaglutide significantly red...

Jorge Plutzky, P. Bogdański, H. Colhoun et al. · 1 citation
Open access Sep 2026

Semaglutide and cardiovascular risk reduction: a mediation analysis of the SELECT trial.

BACKGROUND AND AIMS In SELECT, subcutaneous semaglutide (target dose 2.4 mg) weekly in adults with pre-existing cardiovascular disease and body mass index ≥27 kg/m2 without diabetes significantly reduced major adverse cardiovascular events (MACE) by 20% vs placebo. This analysis explored potential mediators of this car...

H. Colhoun, A. Lincoff, D. Ryan et al. · 0 citations

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