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Author

Jos Jonkers

2 papers indexed here

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Open access Sep 2026

The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss.

BRCA1-linked cancers contain abundant ~10 kb 'Group 1' tandem duplications (TDs). Group 1 TDs form at a Tus/Ter replication-fork barrier in DNA-end resection-defective mouse embryonic stem (mES) cells lacking Brca1 exon 11. To elucidate how BRCA1 suppresses Group 1 TDs, we analyzed Brca1 coiled-coil (CC)-domain mutants...

N. Nilavar, Alberto Marin-Gonzalez, F. Menghi et al. · 0 citations
Review Jul 2026

Beyond the traditional dish: advanced 3D ex vivo culture platforms for tumor modelling.

The tumor microenvironment (TME) and its complex, dynamic interactions play a pivotal role in cancer development, progression and therapy response. However, faithful recapitulation of the diverse cellular and structural components of the TME in vitro remains a major challenge in cancer research. Traditional 2D cancer c...

K. Strepi, Roos F Koppenol, Jos Jonkers et al. · 0 citations

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