Author

José A. Cancelas

3 papers indexed here

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Review Sep 2026

From blood to biotherapies: A brief historical perspective

Transfusion medicine represents the earliest and most enduring example of biotherapy, originating with Blundell's first successful human blood transfusion in 1818 and transformed into a precise, reliable treatment through Landsteiner's discovery of the ABO blood group system in 1901. These foundational advances establi...

José A. Cancelas, M. Delaney, R. Schäfer · Transfusion · 0 citations

Sep 2026

Melatonin, circadian metabolism, mitochondrial remodeling, and cell size dynamics in primitive hematopoietic stem cells.

Primitive hematopoietic stem cells (pHSCs) sustain lifelong hematopoiesis through tightly regulated transitions between quiescence and activation. Circadian oscillations influence hematopoiesis; however, the mechanisms coordinating metabolic state and stem cell function daily remain incompletely defined. Here, we show...

Priyasmita Chakrabarti, Abhishek K. Singh, Nicola K. Wilson et al. · Blood · 0 citations

Sep 2026

Spatially confined IL-12 programs CAR-NK through mTORC1 to coordinate antitumor immune networks.

Solid tumors evade immunotherapy because of immunosuppressive microenvironments that limit immune cell persistence and function. Although interleukin-12 (IL-12) potently activates antitumor immunity, its clinical use has been constrained by systemic toxicity. Here we engineered a CAR natural killer (NK) cell platform t...

Mubin Tarannum, K. Dinh, Mila Stanojevic et al. · Cancer Discovery · 0 citations