Author

José Alquicira-Hernández

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Open access Sep 2026

Efficient genome-wide mapping of reproducible, context-dependent eQTLs at single-cell resolution

Dynema (Dynamic eQTL mapping in single cells) is proposed for fast and accurate genome-wide mapping of context-dependent and independent eQTL effects at true single-cell resolution and shows that TSPAN32 and other autoimmune loci colocalize with cell-state-dependent eQTLs.

José Alquicira-Hernández, E. Dorans, Yoshihiro Tomofuji et al. · bioRxiv · 0 citations

Open access Aug 2026

Efficient genome-wide mapping of reproducible, context-dependent eQTLs at single-cell resolution

Single-cell technologies enable linking disease-risk variants to gene regulatory effects in specific cell-state contexts. However, most so called “single-cell eQTL” studies use a “pseudobulking” strategy to identify expression Quantitative Trait Loci (eQTLs), obscuring subtle dynamic regulatory effects of disease allel...

José Alquicira-Hernández, E. Dorans, Yoshihiro Tomofuji et al. · bioRxiv · 0 citations