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Author

José C. Mateus

2 papers indexed here

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Open access Sep 2026

Distinct Arp2/3 isocomplexes drive axonal actin ring assembly and integrity

The actin-related protein 2/3 (Arp2/3) complex is a central nucleator of branched actin filaments, essential for numerous cellular processes. Using superresolution imaging, we demonstrate that Arp2/3 is a component of the membrane periodic skeleton (MPS)—a highly ordered actin ring-spectrin lattice in the submembrane a...

A. R. Costa, Teresa Lopes, Luís P. Rodrigues et al. · 0 citations
Open access Jul 2026

Closed-loop control of in vitro neuronal activity using reinforcement learning after in silico pre-training

In silico-to-in vitro transfer strategy that achieves efficient state-dependent control of network bursting in cultured neurons is demonstrated and it is demonstrated that effective control policies can be derived in biophysically calibrated digital twins and transferred directly to living networks.

Eduardo Carvalho, José C. Mateus, Ricardo Pinto et al. · 0 citations

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