Author

Joseph DeSautelle

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Open access Sep 2026

A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid Tumors

The eradication of solid tumors by chimeric antigen receptor (CAR) T cells requires dynamic therapies capable of outlasting an immune suppressive tumor microenvironment (TME). However, biological barriers—including rapid exhaustion, poor expansion, and loss of stem-like memory—quickly neutralize these therapies1. Becau...

Rupesh H. Amin, Kevin G. Haworth, H. Moffett et al. · bioRxiv · 0 citations

Open access Aug 2026

Protein design to broadly reprogram engineered T cell function

OutLAST Regulators are designed proteins that reprogram critical T cell signaling pathways to enhance functional persistence and are implemented as compact genetic modules compatible with standard viral vectors and cell therapy manufacturing processes, creating a powerful platform for programming new functions into enh...

S. Boyken, Sean A. Merillat, Robert A. Langan et al. · bioRxiv · 0 citations