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Joseph F. Quinn

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Open access Aug 2026

The TREM2 targeting small molecule Sob-AM2 improves cognition independent of Aβ plaque alteration in 5xFAD mice

The results suggest that the cognitive-enhancing effects of Sob-AM2 are not the result of reduced overall plaque burden, and future work is needed to further investigate the neuroprotective mechanism of Sob-AM2 and how it may be affecting microglial phenotypes.

Lucas Kuhnau, Gisselle A. Jimenez, Wyatt Hack et al. · 0 citations

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