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Author

Joseph P. LaMorte

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Open access Oct 2026

Combining RNA-seq and proteomics boosts sensitivity to detect differentially expressed genes by rpMeta

Differential gene expression analysis is a powerful technique to characterize biological systems. Differentially expressed genes (DEGs) are commonly identified by analysis of RNA sequencing datasets or mass spectrometry proteomics datasets. Increasingly, multi-omic studies include both RNA sequencing and proteomics fro...

Xi-Jun Zhang, Joseph P. LaMorte, Robert L. Kortum et al. · 0 citations
Open access Sep 2026

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity

It is found that the requirement for wild-type RAS to support mutant NRAS–driven transformation correlated with codon-specific differences in GTP hydrolysis, which defines the signaling partnership between mutant NRAS and wild-type HRAS as a targetable vulnerability and provides a biochemical blueprint for dual RAS inh...

Hyun Lee, Jacob M. Hughes, Joseph P. LaMorte et al. · 0 citations

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