Author

Joseph R. Podojil

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Open access Jul 2026

Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model 2261163

The findings show that NMOSD is driven by antigen-specific T and B cell responses, amplified by IFN-I and innate CNS dysregulation, and PLGA(AQP4) therapy re-establishes tolerance and offers a translational strategy for CNS autoimmunity.

G. Arellano, Mac Zelazny, T. Neef et al. · Journal of Immunology · 0 citations

Open access Jul 2026

Complement Activation and Anti-Aquaporin-4 Antibodies Drive Pathology in a Preclinical Model of Neuromyelitis Optica Spectrum Disorder 2261227

The data establish anti-AQP4 antibodies and the C3-C5 (MAC) complement axis as central drivers of NMOSD pathology, reinforcing their value as biomarkers and therapeutic targets.

G. Arellano, Mac Zelazny, Joseph R. Podojil et al. · Journal of Immunology · 0 citations