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Author

Joseph R. Shaw

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Review Oct 2026

Thrombin Generation in Critically Ill Adults: A Systematic Review of Venous Thromboembolism and Pharmacological Thromboprophylaxis.

BACKGROUND Venous thromboembolism (VTE) remains an important complication in critically ill adults despite standard pharmacological thromboprophylaxis. Thrombin generation assays (TGAs) offer a global functional assessment of coagulation by capturing the kinetics and magnitude of thrombin formation and may complement c...

Caseng Zhang, K. Durr, Marc Carrier et al. · 0 citations
Review Aug 2026

Thrombin generation and the pharmacodynamics of oral anticoagulants.

A unified theoretical framework is established, grounded in mechanistic rationale and supported by experimentation, to better define the pharmacodynamics of anticoagulation therapy using thrombin generation as a common language to compare anticoagulant effects across drug classes.

Joseph R. Shaw, Dylan Burger, J. Vassart et al. · 0 citations

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