Author

Joseph W. Downey

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Open access Sep 2026

Neuroimaging of indoleamine 2,3-dioxygenase 1 (Ido1) in Alzheimer's disease: Development of a novel 18F-labeled PET tracer

A novel PET tracer, [18F]XW-032, was developed via ruthenium-mediated deoxyfluorination and effectively visualized regional IDO1 heterogeneity in the AD brain, positioning it as a potent molecular tool for early AD diagnosis and for monitoring the efficacy of IDO1-targeted therapeutic interventions.

Hua Cheng, Nilay S. Narayan, Yong-Le Wang et al. · Materials Today Bio · 0 citations

Open access Sep 2026

Quantitative μ-Opioid Receptor PET with [18F]FCFN in Nonhuman Primates: Naloxone Blockade and Within-Scan Displacement

Background/Objectives: Quantitative PET imaging of μ-opioid receptor (MOR) availability and pharmacologic engagement can advance in vivo studies of opioid receptor biology. We previously evaluated a series of 18F-labeled carfentanil analogs and prioritized the regioisomer [18F]fluorocarfentanil ([18F]FCFN) based on fav...

Evan Gallagher, Joseph W. Downey, Chi-Hyeon Yoo et al. · Pharmaceutics · 0 citations