Prediction of blood-brain barrier permeability using modified poly(dimethylsiloxane).
Blood-brain barrier (BBB) permeability of drugs is fundamental to understand yet incredibly difficult to measure, or even, predict. This study proposes the adoption of a chemically modified form of poly(dimethylsiloxane) (PDMS) as an in vitro biomedical mimic of the BBB for pharmaceutical analysis. Initially, a series...