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Open access Jul 2026

CDState Resolves Malignant Cell Heterogeneity from Bulk Tumor RNA-Sequencing Data.

CDState, an unsupervised deconvolution method based on nonnegative matrix factorization with a sum-to-one constraint and a cosine-similarity-based optimization, which infers malignant cell states using bulk RNA-seq data, is demonstrated to be utility for characterization of malignant cell states from bulk RNA-seq data.

Agnieszka Kraft, Josephine Yates, Florian Barkmann et al. · 0 citations

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