Author

Joshua A. Hull

2 papers indexed here

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Open access Oct 2026

IgM-and IgG-cleaving enzyme facilitates AAV gene transfer in AAV-seropositive macaques.

AAV gene therapy is a promising approach for long-term delivery of antiviral proteins that can control HIV replication, but pre-existing circulating AAV-specific antibodies can preclude successful AAV transduction and pose a challenge for AAV vector re-administration in cases where transgene protein expression falls be...

Helen L. Wu, Z. Elmore, Mark A. Ochoa et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

MADCAP: isolation of novel nAb-naïve AAV capsids from metagenomic data

This work establishes metagenomic mining as a powerful tool for accelerating AAV capsid discovery, identifying isolates with favorable tissue tropisms and resistance to broadly neutralizing antibodies.

E. Lyashenko, Tess Torregrosa, Alexandra B. Ysasi et al. · Journal of Virology · 0 citations