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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Joshua D. Gross

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Review Sep 2026

Bias from within: intracellular allosterism and the ICL2 hub.

Targeting the orthosteric site of G protein-coupled receptors (GPCRs) has long dominated drug discovery, but intracellular allosteric modulators (AMs) provide new avenues to enhance selectivity and fine-tune signaling. Recent structural advances have illuminated intracellular allosteric pockets that act as conformation...

Yang Zhou, Alan Long, Joshua D. Gross et al. · 0 citations

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