Oct 2026
Integrative single-cell transcriptomics and experimental validation reveal that Tusizi Formula ameliorates premature ovarian insufficiency by preserving the primordial follicle pool and promoting granulosa cell differentiation.
BACKGROUND Premature ovarian insufficiency (POI) is characterized by reduced ovarian reserve and disrupted folliculogenesis, often driven by granulosa cell (GC) dysfunction. Traditional Chinese medicine formula TSZF has been widely used for POI, yet its mechanisms and active components remain unclear. This study aimed...
Si-Qi Li, Yuan Li, Jian-Ying Kang et al.
· Tissue & Cell · 0 citations