Author

Joshua L. Wort

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Open access Aug 2026

Structural basis of the gating mechanism of the large-conductance mechanosensitive channel from Escherichia coli

Three cryo-EM structures of EcMscL in two different lipid environments and two distinct conformational states are solved; closed and open-like, guided by EPR.

Katie Hardman, Joshua L. Wort, Qaiser Waheed et al. · Nature Communications · 1 citation

Review Open access Jul 2026

Investigating membrane protein conformational dynamics and noncovalent interactions via electron paramagnetic resonance spectroscopy.

The advent of machine learning structural prediction tools has largely accelerated bottom-up structural biology and provides static Anfinsenian models with near-experimental accuracy, complementing X-ray crystallography and cryogenic electron microscopy. However, these techniques often overlook two fundamental aspects...

Joshua L. Wort, Xinyu Liu, James Pullen et al. · Current Opinion in Structura... · 0 citations