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Joshua McHale

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Open access Oct 2026

Modular multifunctional 5HP2O linkers for the versatile assembly of protein-oligonucleotide conjugates

As complex biotherapeutics continue to evolve, the demand for single-site, multi-functionalized protein conjugates intensifies. Current methods often suffer from maleimide-related hydrolytic instability or require multi-step invasive protein modifications. Here, we establish 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5H...

Jan H. Meffert, Alexandros Kostakis, Joshua McHale et al. · 0 citations

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