Isoform selective targeting of histone deacetylases as a precision therapeutic strategy for neurodegenerative diseases
Histone deacetylases (HDACs) are epigenetic enzymes that eliminate acetyl groups from histone lysine residues, promoting chromatin compaction and transcriptional repression. Dysregulation of HDAC activity is increasingly recognized as a central contributor to the pathogenesis of major neurodegenerative diseases, includ...