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Overall, the dose of IMX was insufficient to attenuate PKR activation and failed to improve muscle function or prevent pathology in dystrophic skeletal muscle.
Findings indicate that dystrophic diaphragms experience ferroptotic stress that is actively constrained, likely by compensatory GPX4 changes, and partially offset disease-related changes in iron-handling and antioxidant proteins.
The cardiovascular system is particularly vulnerable to damage from severe environmental heat stress in both man and animals, particularly during exertion. However, the mechanisms underlying this vulnerability are not well understood, and the potential long-term impacts in surviving patients with sub-clinical symptoms...
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