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Joshua Tomkins

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Open access Aug 2026

Bioinspired peptide cyclisation enables exploration of cytochrome P450 catalysed sequential oxidation in rufomycin biosynthesis

The recently developed peptide cyclisation chemistry is used to produce a library of natural product peptide analogues to study the rufomycin tailoring CYP, RufM, and explore the complex interplay of enzyme catalysed and spontaneous transformations involved in RufM oxidation, suprising RufM substrate promiscuity and th...

Jessica Peate, Yao-Yu Ding, Joshua Tomkins et al. · 0 citations

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