Author

Jospeh C. Wu

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Sep 2026

Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.

Through high-throughput screening, this work identified CGS15943 (CGS) as the lead antifibrotic compound and validated its activity in human cardiac fibroblasts, three-dimensional engineered heart tissues, and animal models of HF.

Hao Zhang, Rabindra V. Shivnaraine, Lu Ren et al. · Science · 0 citations

Review Aug 2026

Induced pluripotent stem cells from discovery to translation

This Review evaluates the technological and translational trajectories that have defined the iPSC era and analyzes the operational barriers to therapeutic development, envisioning a paradigm shift in which iPSC-derived interventions transition from bespoke experimental models toward standardized, engineered biological...

Jaecheol Lee, Todd J. Herron, L. Studer et al. · Nature Medicine · 0 citations