Jothivanan Elumalai

Single-cell mapping of chromosome breaks identifies multiple fragile site classes with distinct DNA replication timing landscapes

Common fragile sites (CFSs) are genomic regions susceptible to chromosome breaks. However, because they were identified using cell populations, low-frequency fragile sites (non-CFSs) could have been overlooked. Here we perform single-cell genome-wide mapping and classification of aphidicolin-induced chromosome breaks....