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Author

Jovana Pavisic

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Sep 2026

Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma

Intratumor heterogeneity and plasticity contribute to resistance, as coexisting tumor cell states exhibit non-overlapping drug sensitivities and divergent responses to therapy. Combination therapy design thus requires identifying vulnerabilities of treatment-persistent populations and measuring state-specific drug ef...

Jovana Pavisic, Chelsey M. Burke, Dao-Qi You et al. · 0 citations
Open access Aug 2026

Integrated multi-omic analysis of pediatric metastatic osteosarcoma reveals endothelial cell plasticity and lineage infidelity

Findings reveal substantial plasticity among endothelial and osteosarcoma cells in human and murine metastatic osteosarcoma, provide new insight into the how the metastatic microenvironment shapes the tumor vasculature, and challenge current models of osteosarcoma biology.

Julian Burks, Ying Wu, Krithika Bhuvaneshwar et al. · 0 citations

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