Joyce W. M. van Bree

Pre-splicing factors associate with UpA-rich RNA and limit flavivirus replication.

The RNA of all living organisms and most viruses exhibits pervasive suppression of uracil-adenine (UpA) dinucleotides, yet the underlying molecular mechanisms remain poorly understood. Here, we use RNA affinity purification coupled with mass spectrometry to identify diverse host factors that preferentially bind UpA-hig...