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Author

Jozef Durko

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Open access Aug 2026

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis

Acute myeloid leukemia (AML) is an aggressive hematological malignancy arising from hematopoietic stem and progenitor cells (HSPCs). Current treatments often fail to eradicate AML; therefore, new therapeutic strategies are essential. Here, we reveal that RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) are dr...

Christopher Mapperley, Elise Georges, A. Azar et al. · 0 citations

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