Open access
Sep 2026
Determination of ETN101, a novel anti-hepatic cancer agent and its two metabolites in rat biological matrices using LC-MS/MS for ADME characterization
ETN101 is a new therapeutic candidate with anti-hepatocellular carcinoma activity. In the present study, three complementary liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods using protein precipitation and matrix-matched calibration were developed for quantifying ETN101 and its metabolites M1 and M2 in...
Woohyung Jung, Eunbee Jang, Yeoun-Hee Kim et al.
· Frontiers in Pharmacology · 0 citations