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Author

J. An

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Oct 2026

Multi-omics reveals evolution from CD7-negative T cell dysregulation to EBV-positive LPD after CD7 CAR-T therapy.

EBV activation specifically occurs in a subset of patients following CD7 CAR-T therapy, subsequently leading to EBV-positive lymphoproliferative disorder (EBV+ LPD), descriptively referred to as post-CD7 CAR-T lymphoproliferative disorder (PCLD) in this study. To comprehensively characterize PCLD, we employed single-nu...

Meng-Meng Huang, Yu-Jia Jiang, Fang Ye et al. · 0 citations
Aug 2026

Multimodal brain cell atlas across the adult macaque lifespan.

A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...

Xiao Zhang, Guang-Shun Lai, Xiang-Yu Guo et al. · 0 citations
Aug 2026

A single-nucleus chromatin accessibility atlas reveals epigenetic dynamics in aging mouse skeletal muscle.

The epigenetic mechanisms underlying the transition of healthy type IIb myonuclei into Ampd3+ myonuclei, revealing key chromatin remodeling events that drive this phenotypic shift are delineated, helps understand the epigenetic events underlying mammalian skeletal muscle aging.

J. An, Guang-Shun Lai, Jing Zuo et al. · 0 citations

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