Open access
Aug 2026
D-mannose blocks S-adenosylmethionine generation to suppress macrophage IL-1β expression
Background and aims Inflammatory stimuli drive metabolic reprogramming in macrophages, supplying energy, reducing equivalents, and methyl donors required for the production of inflammatory mediators such as IL-1β; however, metabolic strategies to regulate this pathway remain unclear. Here, we aimed to define the mechan...
Yingyi Chen, Junji Xu, Jing-Fei Fu et al.
· Frontiers in Immunology · 0 citations