The stimulator of interferon (IFN) genes (STING) pathway has garnered considerable attention due to its significant potential in anti-cancer effect. However, cyclic dinucleotides (CDNs), which are natural agonists or their derivatives for STING, are often hindered by their inherent properties of poor transmembrane pe...
Li-Ru Shang, Lin Peng, Zhang-Ping Huang et al.· Molecular Pharmaceutics· 0 citations
MicroRNAs (miRNAs) have emerged as important biomarkers for cancer diagnosis and prognosis, yet their accurate detection remains challenging due to low abundance, short sequences, and sequence homology. Herein, we report a novel biosensing platform based on a cascade cis-cleavage-triggered split activator assembly stra...
Shui-Fang Xiao, Qian-Qian Deng, Qun Wan et al.· Biosensors & bioelectronics· 0 citations
This reagent-minimal, modular NEP platform provided a high-efficiency, low-toxicity route for saRNA delivery into hard-to-transfect immune cells, offering a versatile engineering framework for DC-based cancer immunotherapy, RNA vaccine development, and broader cell gene-modification applications.
Bowen Zhang, Yi-Jing Cai, Caiguanxi Deng et al.· Microsystems & Nanoengineeri...· 0 citations
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