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Juan José de la Cruz-López

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Open access Sep 2026

Molecular Dynamics Simulations Reveal Structural Changes Associated with the ABCA1 R230C Functional Variant

R230C acts as a dynamic allosteric modulator and membrane-coupling agent rather than a folding-disruptive mutation, providing a biophysical rationale for reduced cholesterol efflux and low plasma HDL-C levels.

Juan José de la Cruz-López, Luis Ramón Tercero Martínez-González, Cecilia Albortante-Morato et al. · 0 citations

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