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Juan José Parra Serpa

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Review Open access Sep 2026

Immunometabolic Dysregulation and Cognitive Dysfunction in Major Depressive Disorder: The Role of Chronic Low-Grade Inflammation

Major depressive disorder is a heterogeneous psychiatric condition frequently accompanied by persistent cognitive dysfunction involving executive function, attention, memory, processing speed, and motivational processes. Increasing evidence suggests that chronic low-grade inflammation and immunometabolic dysregulation...

Juan José Parra Serpa, Catalina Antonia de Jesús, Anabel Stephanny Ortiz Dávila et al. · 0 citations
Review Open access Aug 2026

Early Neuropsychiatric and Cutaneous Manifestations as Sentinel Signs of Systemic Disease

The reviewed evidence showed that systemic lupus erythematosus presented the broadest clinical heterogeneity, while neurological manifestations in Sjögren syndrome may precede classical glandular symptoms.

Jocelyne Keren Hinojosa Villanueva, Luis Felipe Espinal Pérez, Juan José Parra Serpa et al. · 0 citations
Review Open access Aug 2026

Retinal Vascular Biomarkers for Neurovascular and Multiorgan Risk Assessment: From Fundus Imaging to Predictive Oculomics

Retinal imaging may complement conventional vascular-risk assessment by identifying high-risk phenotypes and supporting targeted systemic evaluation, but it should not replace neuroimaging or specialized cardiovascular, neurological, or renal assessment.

Adrian Jhair Flores Equilea, Natalia Restrepo Hinestrosa, Juan José Parra Serpa et al. · 0 citations
Review Open access Sep 2026

Beyond Primary Psychiatry: Medical Causes of Neuropsychiatric Symptoms and an Interdisciplinary Diagnostic Approach

Findings indicate that the differential diagnosis of neuropsychiatric symptoms should not rely exclusively on psychiatric phenomenology, and a structured approach integrating temporal evolution, neurological and systemic warning signs, targeted complementary testing, and interdisciplinary evaluation may improve the rec...

Robinson Alexander Morey Contreras, Gary Bastian Medina Jimenez, A. Lazaro et al. · 0 citations
Review Open access Jul 2026

Rebuilding Function After Stroke: Emerging Technologies and New Frontiers in Neurological Recovery

Current evidence supports digital technologies as complementary components of multidisciplinary stroke rehabilitation rather than substitutes for conventional therapy, and future research should prioritize standardized protocols, multicenter studies, long-term functional outcomes, cost-effectiveness, equitable accessib...

Benitez Barrios Sosimo Isaac, Melany Patricia Bolagay Apráez, Robinson Alexander Morey Contreras et al. · 0 citations
Review Open access Jul 2026

CRISPR-Based Genome Editing in Contemporary Clinical Medicine: Therapeutic Translation, Global Challenges and the Future of Precision Medicine

CRISPR has progressed from an experimental genome-engineering technology to a clinically relevant therapeutic platform, although its future impact will depend on the ability to combine molecular precision and durable therapeutic benefit with rigorous safety assessment, responsible governance, and equitable access acros...

Gabriel Alejandro Ortega Moreno, Gerardo Amaya Villagran, A. González et al. · 0 citations

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