Author

Juan Li

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Open access Aug 2026

Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation

A high-glucose microenvironment is a key feature of tumor metabolic reprogramming that promotes lung cancer cell progression. Previous studies have revealed that protein arginine methyltransferase 5 (PRMT5) is overactivated in various cancers and regulates neddylation of the tumor suppressor phosphatase and tensin homo...

Lei Zheng, Juan Li, Chao Song et al. · Oncology Letters · 0 citations

Open access Aug 2026

Spatial remodeling of inflammatory niches drives stemness acquisition and malignant transformation during early gastric tumorigenesis.

This study uncovers spatially organized inflammatory niches that precede and promote early gastric tumorigenesis by linking precancerous inflammation to stemness acquisition through spatial microenvironmental remodeling, highlighting a critical, targetable window for early intervention in GC.

Tiantian Du, Hui-Ru Gao, Jie Gao et al. · Chinese Medical Journal · 0 citations