Neuronal activity-regulated histone demethylase KDM7A controls hippocampal gene expression and behavior.
It is shown that KDM7A is required for the proper transcriptional regulation of genes implicated in neuronal physiology and synaptic plasticity and that KDM7A-deficient mice display hyperlocomotion, reduced anxiety-like behavior, decreased sensitivity to pro-epileptic agents, and task-dependent changes in cognitive per...