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Author

Juan Peter Timothy Yuune

2 papers indexed here

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Oct 2026

DeepRAGIL-2: a retrieval-augmented protein language model framework for sensitive and accurate prediction of IL-2-inducing peptides.

Interleukin-2 (IL-2) is a pleiotropic cytokine central to T-cell activation, proliferation, and immunological tolerance, yet existing computational tools for predicting IL-2-inducing peptides suffer from near-zero sensitivity under realistic class-imbalanced conditions, rendering them impractical for positive-class dis...

Juan Peter Timothy Yuune, Van-The Le, Yu-Yen Ou · 0 citations
Sep 2026

NeoGen-BC: A synergistic framework combining generative protein language models and multi-window deep learning for designing shared neoantigens in breast cancer.

Breast cancer, particularly hormone receptor-positive (HR+) and triple-negative (TNBC) subtypes, is often immunologically "cold," limiting immunotherapy efficacy. Neoantigen-based vaccines hold promise but face challenges from inaccurate identification and overreliance on HLA binding affinity, which poorly captures tru...

Van-The Le, Juan Peter Timothy Yuune, Jiun-I Lai et al. · 0 citations

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