DeepRAGIL-2: a retrieval-augmented protein language model framework for sensitive and accurate prediction of IL-2-inducing peptides.
Interleukin-2 (IL-2) is a pleiotropic cytokine central to T-cell activation, proliferation, and immunological tolerance, yet existing computational tools for predicting IL-2-inducing peptides suffer from near-zero sensitivity under realistic class-imbalanced conditions, rendering them impractical for positive-class dis...