Juan Toledo-Marcos

A supramolecular complex of palmitoylated Orai C-terminal peptide and cyclodextrin targets the plasma membrane to reduce store-operated calcium channel activity

Palmitoylation is a widely employed strategy for anchoring peptides to lipid membranes, but it can also lead to uncontrolled self-assembly. The lipid moieties can promote clustering into heterodispersed aggregates that distribute unevenly, thereby reducing accessibility and inducing undesired uptake mechanisms that lim...